Carterra Ultra®’s High Sensitivity and Speed Benefit Antibody Binding Kinetics and Epitope Binning Analysis
Key Highlights
- Carterra Ultra combines high-throughput SPR with enhanced sensitivity and faster sample handling,supporting high-quality kinetic and epitope binning measurements across a broad range of interactions, from fragments and small molecules to antibody-based systems.
- Carterra Ultra enables rapid epitope binning workflows, completing 96 × 96 sandwich experiments in under 24 hours and 190 × 190 runs in under 48 hours, while requiring only 200 μL per injection.
- Enhanced sensitivity enables confident measurements at very low response levels, including epitope binning below 5 RU and reliable small-molecule kinetic fits at approximately 2 RU Rmax.
- Carterra Ultra supports both small- and large-molecule interaction analysis across a broad kinetic range, with demonstrated applications spanning ~100 Da analytes, IgG capture kinetics, VHH-Fc interactions, and very fast association to very slow dissociation kinetics.
The Carterra Ultra expands the high-throughput SPR ecosystem with rapid data acquisition, an advanced flow-cell design, and precise referencing across a broad range of applications. While engineered to enable fragment and small-molecule screening, the Carterra Ultra also performs exceptionally well for larger-molecule interactions, combining the throughput of the Carterra LSA and LSAXT platforms with sensitivity improvements that add resolution and capability to challenging binding measurements. Carterra Ultra also has lower sample consumption and faster sample handling than the LSA platforms, speeding up workflows and reducing analyte requirements.
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