Proximity-Based Degraders

Proximity-Based Degraders

Reimagine characterization of TPDs, PROTAC®s, LYTACs, AUTACs, RIBOTACs, and molecular glues using HT-SPR to gain truly meaningful throughput and multiplexing capabilities. One-on-many fluidics reduce sample quantities, consumable costs, and hands on time. Characterize binary and ternary kinetics for hundreds of interactions in parallel. Develop broad and nuanced views of cooperativity in the context of selectivity for up to hundreds of molecules in parallel.

• Throughput: Reduce assay run time and preserve activity of fragile targets/ligases
• Cooperativity: Be confident in the cooperativity values by inclusion of multiple replicates and controls
• Selectivity: Assess binding across up to hundreds of targets and off-targets simultaneously

Ternary kinetic profiles of MZ1/VHL mixture binding to an array of 96 bromodomain proteins. 1:1 Langmuir fit lines in red.

Cooperativity plot derived from binary and ternary affinities of bromodomain proteins in conjunction with MZ1 and VHL.