Antibodies

Categorizing mAbs by kinetics AND epitope is much more relevant than affinity ranking alone, as a mAb’s epitope is an innate property that cannot be rationally enhanced by engineering and ultimately relies on empirical selection. Affinity, on the other hand, can be improved through rational design once the desired epitope is selected.

Identifying mAbs targeting unique epitopes is therefore highly desirable from a discovery perspective because they may offer mechanistically differentiated MOA’s and highly valuable IP opportunities. Epitope screening only a subset of a panel due to throughput limitations restricts epitope diversity, thereby negatively impacting the success of therapeutic drug discovery.

Carterra’s LSA High Throughput SPR instrument delivers the throughput and ease of use to enable high throughput epitope binning.

Kinetics Software

Kinetics Data Analysis Software The Kinetics application software from Carterra changes the paradigm, delivering high throughput kinetics screening capabilities. Key features: High throughput: Screen and rank up to 1,152 mAbs Rapid data analysis: Large data sets can be rapidly fitted and visualized and then validated against several data quality parameters Detailed data mining: Interrogate mAb […]

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Epitope Software

Epitope Data Analysis Software The Epitope software was designed to process the massive data sets created by the HT SPR technology from Carterra, where 384 ligands can be tested against 384 analytes. Prior to the development of this software, the data analysis of even small epitope binning panels could be a time intensive and laborious […]

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High Throughput Kinetics

The LSA changes the paradigm, delivering flow-based kinetics for coupled (up to 384 in parallel) and capture (up to 1152 in a single run) formats, enabling rapid screening of mAb libraries for affinity, association and dissociation constants.

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Epitope Binning

Characterize and group (bin) up to 384×384 mAbs by the epitope binding regions generated against a specific antigen using the LSA’s simple to use classical and pre-mix methods to maintain epitope diversity and provide important information to broaden intellectual property protection.

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Quantitation

Rapidly determine the mAb concentration of up to 1152 clones in parallel to aid in production QC and subsequent screening and selection using the LSA Quant App.

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Epitope Mapping

Antibody epitope discovery at the amino acid level by immobilizing a panel of up to 384 biotinylated peptides with overlapping sequences and screening mAbs to ‘map’ and compare their binding.

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Therapeutic Areas

Therapeutic Areas

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Antibody Formats

Antibody Formats

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