HT-SPR Technology
With Options
Our Surface Plasmon Resonance (SPR) platforms can transform your label-free characterization workflows allowing screening and characterization for both large and small molecules in a single step.
“The resulting speed at which this drug discovery and development effort proceeded, with progression to human treatment only 90 days after the initiation of antibody screening, was due to advanced discovery and characterization platforms….”
Eli Lilly
Science Translational Medicine
Which instrument is right for your application?
| Maximize Analyte Throughput | Maximize Ligand Throughput | |||
|---|---|---|---|---|
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| Crude/purified antibody kinetics | ✓ | ✓ | ✓ | ✓ |
| Crude/purified epitope binning | ✓ | ✓ | ✓ | ✓ |
| Peptide/mutant mapping | ✓ | ✓ | ✓ | ✓ |
| Blockade | ✓ | ✓ | ✓ | ✓ |
| Polyspecifity | ✓ | ✓ | ✓ | ✓ |
| Quantitation | ✓ | ✓ | ✓ | ✓ |
| Peptide analytes | ✓ | ✓ | ✓ | |
| Fc Receptor Affinity | ✓ | ✓ | ✓ | |
| DEL compounds | ✓ | ✓ | ✓ | |
| PROTAC®s/molecular glues | ✓ | ✓ | ✓ | |
| Kinase | ✓ | ✓ | ✓ | |
| Membrane proteins | ✓ | ✓ | ✓ | |
| Ligandability | ✓ | ✓ | ||
| Thermodynamics | ✓ | ✓ | ||
| Small molecules (mM to subnanomolar) | ✓ | ✓ | ||
| Fragment Screening | ✓ | |||
| Learn More | Learn More | Learn More | Learn More | |
Instrument Highlights
| LSA | LSAXT | Carterra Ultra | Carterra Vega | |
|---|---|---|---|---|
| Format | One on Many (single analyte, many ligands) |
Many on Few (many analytes, few ligands) |
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| Antibodies and Biologics Detailed antibody kinetic and epitope binning |
Antibodies and Biologics Enhanced data quality for antibody discovery |
Antibodies, Biologics, Small Molecules, and Fragments Most versatile platform for small molecule and biological discovery |
Fragments, Small Molecules, Biologics, and Screening 48-channel parallel screening with walk-away automation |
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| Ligand Array Capacity | 384 | 384 | 192 | 48 channels (2 ligands each) |
| Simultaneous Analyte Delivery | 1 | 1 | 1 | 48 |
| Max. Throughput (analytes/24 h) (baseline/assoc/dissoc in seconds) |
200 (30/60/60) |
200 (30/30/30) |
384 (30/30/30) |
384 × 48 (10/10/10, automation) 340 × 48 (30/30/30, standalone) |
| Performance | ||||
| Analyte MW Sensitivity | ≥ 1000 Da | ≥ 500 Da | ≥ 100 Da | ≥ 100 Da |
| Analysis Temperature | 15–40 °C | 15–40 °C | 10–40 °C | 10–40 °C |
| Sample Handling | ||||
| Injection Volume | MC: 200 μL SC: 270 μL |
MC: 200 μL SC: 270 μL |
MC: 200 μL SC: 200 μL |
MC: 200, or 270 μL (standalone); 100, 200, or 270 μL (automation) SC: 200 or 270 μL |
| Max Sample Capacity | MC: up to 1152 ligands SC: 384 analytes |
MC: up to 1152 ligands SC: 384 analytes |
MC: up to 1152 ligands SC: 768 analytes |
MC: up to 1152 ligands and/or analytes (standalone) Up to 105 × 384-well plates (with automation) |
| Automation | — | — | — | ✓ |
Sensor Chips & Solutions
Choose from ready-to-use and customizable chip chemistries
The right sensor chip is key to getting optimal assay performance. Fortunately, Carterra offers a broad range of chemistries to handle almost any assay imaginable.
- Options include low, medium, and high capacities as well as distinct chemistries depending on the application.
- Premade surfaces simplify assay setup and design for many standard applications further increasing ease of use.
- Alternatively, customizable surfaces allow the attachment of unique molecules
Kinetics Software
Rapidly analyze thousands of kinetic interactions simultaneously.
- Carterra’s Kinetics software easily performs kinetic and steady state affinity analysis on thousands of interactions.
- Automatic data flagging focuses attention on complex data requiring more investigation.
- Advanced analysis features allow seamless display of trends and replicates.
Epitope Software
Explore epitope diversity at an unprecedented level.
Carterra’s Epitope software takes epitope analysis to a whole new level.
- With the ability to compare up to 150,000 interactions from a single experiment, there’s no excuse for not going big when it comes to epitope characterization.
- Cutting edge network plots distill complex data sets into intuitive epitope relationships.
AI, ML & In Silico Tools
Delivering the scale of data needed to develop and validate AI/ML models
Carterra products are the standard for modern drug discovery processes leveraging AI/ML. The scale of data generated enables a robust design and test strategy to build confidence in models.
Plate Loading Robot
Your pipeline doesn’t stop when you do
Carterra’s optional plate loading robot integrates directly with the Carterra Vega platform to deliver true walk-away automation.
- Load your samples, walk away, and let the system run completely unattended — day or night.
- Eliminate bottlenecks caused by manual sample handling and increase the number of experiments per scientist per day.
- Pairs seamlessly with Carterra Vega’s 48-channel flow architecture to maximize throughput across your discovery pipeline.