Drug Discovery 2022 (ELRIG) – London, UK
Conference dates: OCTOBER 4-5, 2022
Location: ExCeL (London, UK)
Stand: A4
Poster session
Poster Presenter: Jon Popplewell
Title: Improving the screening, selection and deep characterization of biotherapeutic molecules using high-throughput SPR
Abstract: Throughput, speed, resolution, and sample consumption are inevitable challenges scientists face when screening biomolecule libraries and working to the goals of discovering and identifying the best lead candidates. Educated selection will often require multiple tests and orthogonal testing confirmation to determine the top candidate. Here we demonstrate how the Carterra LSA, which performs high-throughput surface plasmon resonance (HT-SPRTM) can rapidly generate high quality kinetic data from 384 candidates in parallel using a minimal amount of sample material. In addition, the LSA can perform epitope binning on up to 384 candidates per array to obtain unique epitope discrimination and characterization. The LSA is a high-throughput biology solution that enables scientists to characterize binding kinetics, affinity, and epitope specificity on large protein panels with minimal sample consumption, accelerating library-to-lead candidate selection and discovery.