Conference dates: OCTOBER 12-14, 2022
Booth: 15

Speaking session

Title: Rapid Characterization of Antibody Therapies Targeting High-Value I-O Targets

Speaker: Noah T. Ditto, MS, MBA

Speaker Title: Technical Product Manager, Carterra

Date: Friday, October 14, 2022

Time: 10:00 – 10:30 am EDT

Abstract: In the highly competitive immune-oncology (I-O) space, effective identification and differentiation of potential therapeutics requires a detailed understanding of mechanism of action (MOA). To maximize the value of sophisticated antibody discovery technologies, MOA needs to be understood at the earliest stages of drug discovery. In these initial stages, candidate numbers can measure in the thousands and precious sample quantities are stretched thin across numerous discovery platforms. This talk will focus on a strategy of I-O therapeutic selection supported by high-throughput surface plasmon resonance (HT-SPR) to increase the potential for efficacious and commercially differentiated antibodies. By front loading characterization efforts in the discovery phase, this approach enables an evolving selection of therapeutic leads dependent on program objectives, biological discoveries, and commercial pressure.