Yasmina Abdiche, Chief Scientific Officer of Carterra, will present current advancements in antibody discovery on the main podium of the SLAS conference in Washington, DC on February 4, 2019.
Presentation Title:
Accelerate Library-to-Lead Triage of Antibody Libraries Using High Throughput SPR
Throughput, speed, resolution, and sample consumption are often key limiting factors for performing detailed kinetic and epitope characterization of antibody libraries destined for use as therapeutics or supporting diagnostics and reagents. In addition, antibody immune responses can be used to survey the epitope landscape of pathogens and inform the design of better immunogens for developing vaccines. Here, we demonstrate three core applications of High Throughput SPR that can be performed routinely and quickly in a 384-array format; (1) capture kinetics, (2) epitope binning, and (3) epitope mapping. Together, these assays provide a comprehensive characterization of your antibody library with minimal sample consumption, often less than 5 micrograms per antibody for most applications, enabling more confident decisions to be made earlier in the research process and obviating the need for preliminary ELISA screening.