Conference dates: MARCH 13 -15, 2024

Stand: 55

Location: Novotel London West, Hammersmith, London

Speaking session

Title: Solving Big Data Challenges In Therapeutic Discovery

Speaker: Néstor Vázquez Bernat, PhD, Application Science Team Lead, ENPICOM

Date and Time: Thursday, March 14 at 9:40 am GMT

Location: Conference Room 1

Abstract: High-throughput sequencing and screening are revolutionizing therapeutic discovery. We will discuss how data analysis solutions and emerging AI applications can propel your therapeutic discovery with these large new datasets

Poster session

Title: Selection of DNA Aptamers with Optimal Binding Properties using HT-SPR

Presenter: Jonathan Popplewell, PhD, Field Applications Scientist, Carterra

Abstract: Aptamers hold promise as a class of molecules where interest has surged in recent years. Compared to antibodies, they have differentiated characteristics including being able to be chemically synthesized, lower sterics, more tunable properties, as well as compatibility with cutting edge genomic capabilities such as sequencing and tagging. Improvement of aptamer properties has also overcome historic challenges of enzyme degradation and selectivity. High-throughput surface plasmon resonance (HT-SPR) is a technique for label-free, real-time binding analysis that can be deployed for applications including quantitative kinetics, epitope clustering, and selectivity, which are essential in developing robust and well-understood aptamers. The novel one-on-many configuration of the Carterra LSAXT enables large panels of candidate molecules to be quickly interrogated for the aforementioned properties. Here we describe the process for thorough analysis of DNA-based biotinylated aptamers using HT-SPR to uncover critical binding properties quickly while using very little sample.