Presentation: High-throughput SPR in DNA-encoded library screening and hit validation at GSK

Presented by: Karanbir Pahil, PhD, Investigator, GSK

Abstract: DNA-encoded libraries (DELs) enable drug discovery chemists to identify thousands of hits from screening campaigns using billions of molecules, producing a vast array of small molecule structure-activity relationship data and potentially interesting chemical matter that needs to be triaged efficiently. DELs are made combinatorically, with every library member being assigned a unique DNA barcode, and every step of chemistry being compatible with the presence of DNA. Here, we show how we leverage the facility of resynthesizing DEL screening hits with DNA tags and the Carterra LSA^® platform to enable high throughput binding assays.

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