Key Highlights

  • Screen over a thousand candidates against membrane targets in a single experiment

  • Multiple membrane formats available depending on project objectives

  • One-on-many format requires only very small quantities of membrane targets


Membrane targets make up a substantial part of the overall “undruggable” therapeutic space that has recently garnered widespread interest. Despite encouraging improvements in the tools to screen for therapeutics against membrane-bound targets, there are still many practical limitations owing to the challenges of working with proteins that are not highly stable outside of the cell-membrane environment. High-throughput surface plasmon resonance (HT-SPR) is a powerful technique that is transforming characterization workflows and enabling a greater breadth and depth of information for drug candidates. Here we demonstrate the ability to quantitatively assess binding kinetics for panels of antibodies against membrane receptors. This workflow highlights opportunities to perform detailed binding characterization for up to thousands of drug candidates in parallel.

Posted by Rebecca Rich

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