Prellis Biologics: Rapid Fully Human Antibody Discovery via High-throughput SPR Characterization of Targets with Diverse Formats

Presented by:Jinqiu Wang, PhD, Senior Scientist, Prellis Biologics, Inc

Abstract: The EXIS™ platform at Prellis Biologics accelerates antibody discovery by integrating natural immune processes with advanced AI to navigate the complexity of the human immune repertoire. Using two-photon laser bioprinting, we generate 3D organoids that recapitulate the complexity of immune responses in vitro. Antibodies identified through this platform are characterized using Carterra LSA^XT, supporting a portfolio of fully human therapeutic candidates across multiple disease target areas. Discovery targets span diverse structural formats, including peptides, monomers, multimers, nanodiscs, and virus-like particles. We present optimized screening and analysis strategies that enable efficient characterization and pilot lead selection across these multiple formats.