Presentation: Redefining High-Throughput SPR: The Carterra Vega™ Platform

Abstract

Carterra transformed high-throughput surface plasmon resonance (SPR)–based antibody discovery with the launch of its one-on-384 array LSA platform in 2018. The newly developed Vega platform substantially increases analyte throughput to 48 channels, with each channel containing two ligand spots and a reference. This presentation will introduce Carterra Vega and demonstrate its functionality through two case studies. The first case study describes the use of Vega’s 48-channel injections to simultaneously characterize binding kinetics and specificity of 48 monovalent antibodies against human and cynomolgus forms of a dimeric receptor. The second case study highlights high-throughput screening of a small-molecule library against a target and a counter-target, with rapid confirmation of hit compounds through titration experiments.