The Antibody Series 2022 – Portugal
Conference dates: SEPTEMBER 7-9, 2022
Speaking session
Title: High resolution epitope binning informs antibody drug discovery and enhances next generation antibody workflows
Speaker: Dan Bedinger, PhD, Carterra
Date: Wednesday, September 7, 2022
Time: 17:00 WEST
Abstract: Several recent high-profile examples have been published highlighting the utility of high-resolution competition-based epitope binning in the rapid characterization of diverse monoclonal antibody panels. Detailed competition-based epitope binning can be used to cluster related antibodies into binding classes which inform variant resistance, avidity, and activity. Furthermore, this information can enable a more detailed understanding of mAb sequence sets which are generated from diverse panels of putative binders from next generation sequencing-based discovery approaches. The Carterra LSA and Epitope software enable this analysis at an unrivaled scale and level of detail.