World Bispecific 2023 – Boston
Conference dates: OCT 2-4, 2023
Location: The Colonnade Hotel (Boston, MA)
Speaker session
Title: Fully Integrated Bispecific Antibody Discovery for the Biotechnology Ecosystem
Speaker: Lucy Liu, PhD, Senior Director, Head of Global Bioanalytics, Alloy Therapeutics
Date and Time: Tuesday, Oct 3. 2023, 2:45 pm – 3:15 pm ET
Abstract: Alloy Therapeutics is a biotechnology ecosystem company that democratizes access to tools, technologies, services, and capabilities that are foundational for discovering and developing therapeutic biologics. In this talk, we will show case studies of our bispecific antibody discovery and discuss how Carterra LSA fits into this workflow and supports its efforts to enable the global scientific community to make better medicine together.
Poster session
Poster Title: Large-scale Characterization of Drug Candidates Against Transmembrane Receptors using HT-SPR
Presenter: Nicholas Abuid, Field Application Scientist, Carterra
Abstract: Membrane targets make up a substantial part of the overall “undruggable” therapeutic space that has recently garnered widespread interest. Despite encouraging improvements in the tools to screen for therapeutics against membrane-bound targets, there are still many practical limitations owing to the challenges of working with proteins that are not highly stable outside of the cellmembrane environment. High-throughput surface plasmon resonance (HT-SPR) is a powerful technique that is transforming characterization workflows and enabling a greater breadth and depth of information for drug candidates. Here we demonstrate the ability to quantitatively assess binding kinetics for panels of antibodies against membrane receptors in several formats. This workflow highlights opportunities to perform detailed binding characterization for up to thousands of drug candidates in parallel.