Kinase Inhibitors

Expand selectivity profiling to include up to hundreds of targets and off-targets in replicate in a single experiment. Enable detailed kinetic analysis across weak and high affinity binders in parallel. Distinguish subtle differences in selectivity with a high degree of accuracy. Throughput avoids the need to keep fragile kinases active for days of screening.

Selectivity: Comprehensively screen candidates against hundreds of targets and off-targets
Resolution: Quantitatively determine subtle differences in association and dissociation kinetics
Broad dynamic range: Accurately determine kinetics for both weak and high affinity interactions in the same experiment

Selectivity of sunitinib against panel of kinases in duplicate.

GSK-461364 binding to an array of kinases in duplicate. High selectivity is demonstrated for only PLK1 as expected.