Kinase Inhibitors

Expand selectivity profiling to include up to hundreds of targets and off-targets in replicate in a single experiment. Enable detailed kinetic analysis across weak and high affinity binders in parallel. Distinguish subtle differences in selectivity with a high degree of accuracy. Throughput avoids the need to keep fragile kinases active for days of screening.

Selectivity: Comprehensively screen candidates against hundreds of targets and off-targets
Resolution: Quantitatively determine subtle differences in association and dissociation kinetics
Broad dynamic range: Accurately determine kinetics for both weak and high affinity interactions in the same experiment

Selectivity of sunitinib against panel of kinases in duplicate.

GSK-461364 binding to an array of kinases in duplicate. High selectivity is demonstrated for only PLK1 as expected.

Carterra is pleased to have collaborated with Carna Biosciences to develop kinase drug discovery. The data presented above was generated with kinases from Carna Biosciences. For more information about Carna Biosciences kinase products, click here.