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Reveal the Epitope Diversity of Your Antibody Library Using High Throughput SPR: A Case Study Using Progranulin

https://carterra-bio.com/resources/reveal-the-epitope-diversity-of-your-antibody-library-using-high-throughput-spr-a-case-study-using-progranulin/

…example, a 10 x 10 set of antibodies requires 100 unique tests to complete a bi-directional competition map, whereas a 96 x 96 set would require nearly 10,000 individual analyses….

Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another – January 6, 2017

https://carterra-bio.com/resources/antibodies-targeting-closely-adjacent-or-minimally-overlapping-epitopes-can-displace-one-another/

…biosensors can be used to identify antibodies that compete for closely adjacent or minimally overlapping epitopes on their specific antigen via a mechanism of antibody displacement. By kinetically perturbing one…

Assessing the Binding Properties of the Anti-PD-1 Antibody Landscape Using Label-free Biosensors – March 5, 2020

https://carterra-bio.com/resources/assessing-the-binding-properties-of-the-anti-pd-1-antibody-landscape-using-label-free-biosensors/

…of our methods. The LSA instrument was also used to perform epitope binning and ligand competition studies which revealed over ten unique competitive binding profiles within this group of mAbs….

GPCR and Transmembrane Proteins

https://carterra-bio.com/applications/gpcr-and-transmembrane-proteins/

Benefits of HT-SPR when working with Transmembrane Proteins (TMs) TMs in solution avoid complications with immobilizing on the sensor surface Multiple formats can be used depending on application Detailed kinetics…

Aviva/Carterra Webinar

https://carterra-bio.com/events/aviva-carterra-webinar/

Healthcare Transparency

https://carterra-bio.com/healthcare-transparency/

…out-of-network allowed amounts between health plans and healthcare providers. The machine readable files are formatted to allow researchers, regulators, and application developers to more easily access and analyze data. https://www.cigna.com/legal/compliance/machine-readable-files…

Rapid Adoption of Carterra’s LSA® Instrument Drives European Expansion

https://carterra-bio.com/news/rapid-adoption-of-carterras-lsa-instrument-drives-european-expansion/

…is changing the way biologics are discovered,” says Tim Germann, Carterra’s Chief Commercial Officer. “We’re thrilled to invite European drug developers and the research community at large to experience in…

Strategy for Discovery of Conventional Monoclonal Antibodies

https://carterra-bio.com/resources/a-multiplatform-strategy-for-the-discovery-of-conventional-monoclonal-antibodies-that-inhibit-the-voltage-gated-potassium-channel-kv1-3/

…endeavor exacerbated by difficulties in producing recombinant ion channel proteins in amounts that support drug discovery programs. We have developed a general strategy to address this challenge by combining high-level…

A Natively Paired Antibody Library Yields Drug Leads with Higher Sensitivity and Specificity Than a Randomly Paired Antibody Library – February 1, 2018

https://carterra-bio.com/resources/a-natively-paired-antibody-library-yields-drug-leads-with-higher-sensitivity-and-specificity-than-a-randomly-paired-antibody-library/

…therapeutic antibody candidates in mouse B cell repertoires. In this study, we compare a deep sequencing and scFv display method that retains native heavy and light chain pairing with a…

High-Throughput Epitope Binning of Therapeutic Monoclonal Antibodies: Why You Need to Bin the Fridge – August 1, 2014

https://carterra-bio.com/resources/high-throughput-epitope-binning-of-therapeutic-monoclonal-antibodies-why-you-need-to-bin-the-fridge/

ScienceDirect. 2014 Aug 01; doi: 10.1016/j.drudis.2014.05.011 B. Brooks, A. Miles, Y. Abdiche Wasatch Microfluidics, LLC, 825 North 300 West, Suite C325 Salt Lake City, UT 84103, USA. ben@brooks.nu. Rinat Laboratories,…