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Broad Epitope Coverage of a Human in Vitro Antibody Library – November 21, 2016
https://carterra-bio.com/resources/broad-epitope-coverage-of-a-human-in-vitro-antibody-library/…as a model antigen, combined 3 key capabilities: 1) access to a diverse panel of antibodies selected from a human in vitro antibody library; 2) application of state-of-the-art high-throughput epitope…
Nature Article: Speeding Antibody Screening for Drug Development
https://carterra-bio.com/news/nature-article-speeding-antibody-screening-for-drug-development/
IgG Binding Characteristics of Rhesus Macaque FcγR – October 1, 2016
https://carterra-bio.com/resources/igg-binding-characteristics-of-rhesus-macaque-fc%ce%b3r/J Immunol. 2016 Oct 1; doi: 10.4049/jimmunol.1502252. Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles…
Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses – December 13, 2016
https://carterra-bio.com/resources/biophysical-and-functional-characterization-of-rhesus-macaque-igg-subclasses/…candidate vaccines for evaluation in first in man studies, little is known about the properties of MM immunoglobulin G (IgG) subclasses and how they may compare to human IgG subclasses….
Chickens with Humanized Immunoglobulin Genes Generate Antibodies with High Affinity and Broad Epitope Coverage to Conserved Targets – November 2, 2017
https://carterra-bio.com/resources/chickens-with-humanized-immunoglobulin-genes-generate-antibodies-with-high-affinity-and-broad-epitope-coverage-to-conserved-targets/MAbs. 2017 Nov 02; doi: 10.1080/19420862.2017.1386825 Kathryn H Ching, Ellen J Collarini, Yasmina N Abdiche, Daniel Bedinger, Darlene Pedersen, Shelley Izquierdo, Rian Harriman, Lei Zhu, Robert J Etches, Marie-Cecile van…
A Natively Paired Antibody Library Yields Drug Leads with Higher Sensitivity and Specificity Than a Randomly Paired Antibody Library – February 1, 2018
https://carterra-bio.com/resources/a-natively-paired-antibody-library-yields-drug-leads-with-higher-sensitivity-and-specificity-than-a-randomly-paired-antibody-library/…therapeutic antibody candidates in mouse B cell repertoires. In this study, we compare a deep sequencing and scFv display method that retains native heavy and light chain pairing with a…
Strategy for Discovery of Conventional Monoclonal Antibodies
https://carterra-bio.com/resources/a-multiplatform-strategy-for-the-discovery-of-conventional-monoclonal-antibodies-that-inhibit-the-voltage-gated-potassium-channel-kv1-3/…endeavor exacerbated by difficulties in producing recombinant ion channel proteins in amounts that support drug discovery programs. We have developed a general strategy to address this challenge by combining high-level…
Expert View Article in Drug Target Review
https://carterra-bio.com/news/expert-view-article-in-drug-target-review/
Nature: Germline-encoded Neutralization of a Staphylococcus aureus Virulence Factor by the Human Antibody Repertoire
https://carterra-bio.com/resources/germline-encoded-neutralization-of-a-staphylococcus-aureus-virulence-factor-by-the-human-antibody-repertoire/Nature Communications. 2016 Nov 18; doi: 10.1038/ncomms13376. Y. Yeung, D. Foletti, X. Deng, Y. Abdiche, P. Strop, J. Glanville, S. Pitts, K. Lindquist, P. Sundar, M. Sirota, A. Hasa-Moreno, A….
GEN Article: Eliminating Bottlenecks in mAb Drug Discovery
https://carterra-bio.com/news/gen-article-eliminating-bottlenecks-in-mab-drug-discovery/