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…originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into which replicated natural complementarity-determining regions purged of…

…under the age of 5 years. However, the first malaria vaccine recommended by the World Health Organization (WHO) for pediatric use, RTS,S/AS01 (Mosquirix), has modest efficacy. Complementary strategies, including monoclonal…

…healthy donors. The selection used a combination of phage and yeast display technologies and included counter-selection strategies meant to direct the selection of the receptor-binding motif (RBM) of SARS-CoV-2 spike…

Introduction The unique heterobifunctional nature of PROTACs necessitates expanding the toolbox of characterization techniques to enable efficient drug discovery. Multiple warhead and linker combinations must be tested against the target…

…in kinetic characterization of therapeutic mAbs, but other techniques are commonly used as a primary screening tool due to the low throughput, high sample requirements, and limited data analysis capability…

…this system, the process from the transformation to 384 interaction analyses can be performed within a week. This system utility was tested using an interspecies specificity design of an anti-human…

…the intellectual property (IP) and commercial potential of a therapeutic. Those antibodies with novel MOAs represent significant opportunities in the competitive world of pharmaceuticals, and so identifying them is key….

Drug Discovery 2024 – ELRIG UK…

Drug Discovery Chemistry 2024 – San Diego…

…wealth of compound binding information. Over 80,000 binding interactions were measured during a 3-day label-free screen. Detailed kinetics were then subsequently obtained for hits of interest. Beyond simple yes/no reporting,…