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Addressing Viral Pandemics Such as COVID-19 Using the Carterra LSA

https://carterra-bio.com/resources/addressing-viral-pandemics-such-as-covid-19-using-the-carterra-lsa/

…thousands of samples in a week using ultra-low sample quantities Emerging Diseases Require New Tools Medicines to treat and prevent infectious diseases cover a broad range of modalities from dosed…

Science: LY-CoV555, a Rapidly Isolated Potent Neutralizing Antibody, Provides Protection in a Non-Human Primate Model of SARS-CoV-2 Infection

https://carterra-bio.com/resources/ly-cov555-a-rapidly-isolated-potent-neutralizing-antibody-provides-protection-in-a-non-human-primate-model-of-sars-cov-2-infection/

…through study Day 6 following viral inoculation. This antibody has entered clinical testing and is being evaluated across a spectrum of COVID-19 indications, including prevention and treatment. Introduction The global…

Nature: A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

https://carterra-bio.com/resources/a-pandemic-enabled-comparison-of-discovery-platforms-demonstrates-a-naive-antibody-library-can-match-the-best-immune-sourced-antibodies/

…properties and neutralization activities comparable to the best from hyperimmune sources. This demonstrates that appropriately designed and constructed naïve antibody libraries can effectively compete with immunization to directly provide therapeutic…

GPCR and Transmembrane Proteins

https://carterra-bio.com/applications/gpcr-and-transmembrane-proteins/

Benefits of HT-SPR when working with Transmembrane Proteins (TMs) TMs in solution avoid complications with immobilizing on the sensor surface Multiple formats can be used depending on application Detailed kinetics…

Reveal the Epitope Diversity of Your Antibody Library Using High Throughput SPR: A Case Study Using Progranulin

https://carterra-bio.com/resources/reveal-the-epitope-diversity-of-your-antibody-library-using-high-throughput-spr-a-case-study-using-progranulin/

…example, a 10 x 10 set of antibodies requires 100 unique tests to complete a bi-directional competition map, whereas a 96 x 96 set would require nearly 10,000 individual analyses….

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Antibodies: Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBDoftheSARS-CoV-2 Spike Protein

https://carterra-bio.com/resources/isolation-and-characterization-of-neutralizing-monoclonal-antibodies-from-a-large-panel-of-murine-antibodies-against-rbdofthesars-cov-2-spike-protein/

…Roberto Arriga, Silvia Maria Serrao, Valentina Peluzzi, Eugenia Principato, Mirco Compagnone, Eleonora Pinto, Laura Luberto, Daniela Stoppoloni, Armin Lahm, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Andrew Goodhead, Judicael…

High throughput surface plasmon resonance imaging method for clinical detection of presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during COVID-19 infection

https://carterra-bio.com/resources/high-throughput-surface-plasmon-resonance-imaging-method-for-clinical-detection-of-presence-and-strength-of-binding-of-igm-igg-and-iga-antibodies-against-sars-cov-2-during-covid-19-infection/

…COVID-19. This new high throughput method can be applied for the assessment of the quality of the immune reaction of healthy individuals to SARS-CoV-2 and its mutants in vaccination programs….

Antibody Discovery Industry Leaders Speak at Carterra’s September 18, 2018 Seminar

https://carterra-bio.com/news/antibody-discovery-industry-leaders-speak-at-carterras-september-18-2018-seminar/

Array SPR has facilitated a paradigm shift in antibody screening, enabling higher information content assays to be conducted earlier in the research pipeline to streamline lead selection. This essentially combines…

Surface Plasmon Resonance (SPR) Reveals Direct Binding of HSV Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD – May 15, 2019

https://carterra-bio.com/resources/surface-plasmon-resonance-spr-reveals-direct-binding-of-hsv-glycoproteins-gh-gl-to-gd-and-locates-a-gh-gl-binding-site-on-gd/

…gD, we used multiple anti-gD MAbs from six antigenic communities and determined which ones interfered with this interaction. MAbs from three separate communities block gD-gH/gL binding and their epitopes encircle…