Search

…repertoire, combining VDJ recombination from humanity with somatic hyper-mutation from humanity on the specific frameworks. We then combined that stuff using entirely synthetics framework. So I didn’t want any mutations…

…cell, self-block. 0:20:18.8 TY: So if we zoom in on the lower portion of this heat map, looking at communities that we assigned as five and community 6 and community…

…very similar, competing with each other, competing with basically all the same… And at this level of stringency on the dendrogram, we’re effectively able to communicate confidently that yes, they…

…the frequency also highly comparable of the two groups. 0:33:44.0 DL: And we also did comparison in terms of the identity. So that shows percentage of to the germline. So…

…made in Carterra last December, which has resulted in several collaborations between the companies involving assay development and software integration projects over the past year. Commenting on this latest distribution…

…because it actually relates back to the community data I just showed in the sense that the highest affinity clones that actually competed the best in this competition assay with…

…left and PTM2 on the right, comprise this combination of PTMs. We call one proximal and one distal. What we did was generate recombinant antibody candidates to the combination of…

…of the particular binding domains in the community plots we have purple communities and a blue community indicated on the structure. So again, really early on with not a lot…

…epitope specificity is an innate property that cannot be predicted. The epitope is highly complex and unknown a priori, and the in silico design of an equally complex complementary paratope…

…the CDRs is coming from natural CDRs. There is no synthetic diversity within a CDR. The diversity is coming from the combination or the combinatorials of putting different CDRs together…