Book Chapter
Springer Nature: Epitope Mapping Protocols – Chapter 19: Competitive Epitope Binning Using HT-SPR
Presentation
Presentation: High-throughput biophysical characterization of monoclonal antibodies for identifying epitope diversity at NGM Biopharmaceuticals
Peer-Reviewed Publication
A Natively Paired Antibody Library Yields Drug Leads with Higher Sensitivity and Specificity Than a Randomly Paired Antibody Library – February 1, 2018
Peer-Reviewed Publication
Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential
Peer-Reviewed Publication
Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another – January 6, 2017
Peer-Reviewed Publication
Assessing Kinetic and Epitopic Diversity Across Orthogonal Monoclonal Antibody Generation Platforms – February 1, 2016
Peer-Reviewed Publication
Assessing the Binding Properties of the Anti-PD-1 Antibody Landscape Using Label-free Biosensors – March 5, 2020
Peer-Reviewed Publication
Broad Epitope Coverage of a Human in Vitro Antibody Library – November 21, 2016
Peer-Reviewed Publication
Cell Reports: A Global Collaboration for Systematic Analysis of Broad-ranging Antibodies Against the SARS-CoV-2 Spike Protein
Peer-Reviewed Publication
Chickens with Humanized Immunoglobulin Genes Generate Antibodies with High Affinity and Broad Epitope Coverage to Conserved Targets – November 2, 2017
Peer-Reviewed Publication
Common Light Chain Chickens Produce Human Antibodies of High Affinity and Broad Epitope Coverage for the Engineering of Bispecifics
Peer-Reviewed Publication
Complementary Epitopes and Favorable Developability of Monoclonal Anti-LAMP1 Antibodies Generated Using Two Transgenic Animal Platforms
Peer-Reviewed Publication
Expression of Human Lambda Expands the Repertoire of OmniChickens – January 29, 2020
Peer-Reviewed Publication
Global Sensing of the Antigenic Structure of Herpes Simplex Virus gD Using High-throughput Array-based SPR Imaging – June 14, 2017
Peer-Reviewed Publication
High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity – March 20, 2014
Peer-Reviewed Publication
High-Throughput Epitope Binning of Therapeutic Monoclonal Antibodies: Why You Need to Bin the Fridge – August 1, 2014
Peer-Reviewed Publication
Increased Breadth of HIV-1 Neutralization Achieved by Diverse Antibody Clones each with Limited Neutralization Breadth – December 19, 2018
Peer-Reviewed Publication
Longitudinal Dynamics of the Human B Cell Response to the Yellow Fever 17D Vaccine – March 9, 2020
Peer-Reviewed Publication
Massive Antibody Discovery Used to Probe Structure–function Relationships of the Essential Outer Membrane Protein LptD – June 25, 2019
Peer-Reviewed Publication
Nature Communications: CD229 CAR T Cells Eliminate Multiple Myeloma and Tumor Propagating Cells Without Fratricide
Peer-Reviewed Publication
Nature Communications: Germline-encoded Neutralization of a Staphylococcus aureus Virulence Factor by the Human Antibody Repertoire
Peer-Reviewed Publication
Presence and Strength of Binding of IgM, IgG and IgA Antibodies Against SARS-CoV-2 During COVID-19 Infection
Peer-Reviewed Publication
Rapid Exploration of the Epitope Coverage Produced by an Ebola Survivor to Guide the Discovery of Therapeutic Antibody Cocktails
Peer-Reviewed Publication
Restricted Epitope Specificity Determined by Variable Region Germline Segment Pairing in Rodent Antibody Repertoires – February 10, 2020
Peer-Reviewed Publication
Science Translational Medicine: LY-CoV555, a Rapidly Isolated Potent Neutralizing Antibody, Provides Protection in a Non-Human Primate Model of SARS-CoV-2 Infection
Book Chapter
Springer Nature: Epitope Mapping Protocols – Chapter 19: Competitive Epitope Binning Using HT-SPR
Peer-Reviewed Publication
Strategy for Discovery of Conventional Monoclonal Antibodies
Peer-Reviewed Publication
Surface Plasmon Resonance (SPR) Reveals Direct Binding of HSV Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD – May 15, 2019
Peer-Reviewed Publication
The Importance of Epitope Binning for Biological Drug Discovery – June, 2014
Peer-Reviewed Publication
Vaccine-induced Antibodies to Herpes Simplex Virus Glycoprotein D Epitopes Involved in Virus Entry and Cell-to-cell Spread Correlate with Protection Against Genital Disease in Guinea Pigs – May 23, 2019
Peer-Reviewed Publication
Cell Reports: A Global Collaboration for Systematic Analysis of Broad-ranging Antibodies Against the SARS-CoV-2 Spike Protein
Peer-Reviewed Publication
Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential
Peer-Reviewed Publication
Science Translational Medicine: LY-CoV555, a Rapidly Isolated Potent Neutralizing Antibody, Provides Protection in a Non-Human Primate Model of SARS-CoV-2 Infection
Peer-Reviewed Publication
Common Light Chain Chickens Produce Human Antibodies of High Affinity and Broad Epitope Coverage for the Engineering of Bispecifics
Peer-Reviewed Publication
Rapid Exploration of the Epitope Coverage Produced by an Ebola Survivor to Guide the Discovery of Therapeutic Antibody Cocktails
Peer-Reviewed Publication
Presence and Strength of Binding of IgM, IgG and IgA Antibodies Against SARS-CoV-2 During COVID-19 Infection
Peer-Reviewed Publication
Complementary Epitopes and Favorable Developability of Monoclonal Anti-LAMP1 Antibodies Generated Using Two Transgenic Animal Platforms
Peer-Reviewed Publication
Restricted Epitope Specificity Determined by Variable Region Germline Segment Pairing in Rodent Antibody Repertoires – February 10, 2020
Peer-Reviewed Publication
Longitudinal Dynamics of the Human B Cell Response to the Yellow Fever 17D Vaccine – March 9, 2020
Peer-Reviewed Publication
Assessing the Binding Properties of the Anti-PD-1 Antibody Landscape Using Label-free Biosensors – March 5, 2020
Peer-Reviewed Publication
Nature Communications: CD229 CAR T Cells Eliminate Multiple Myeloma and Tumor Propagating Cells Without Fratricide
Peer-Reviewed Publication
Expression of Human Lambda Expands the Repertoire of OmniChickens – January 29, 2020
Peer-Reviewed Publication
Massive Antibody Discovery Used to Probe Structure–function Relationships of the Essential Outer Membrane Protein LptD – June 25, 2019
Peer-Reviewed Publication
Surface Plasmon Resonance (SPR) Reveals Direct Binding of HSV Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD – May 15, 2019
Peer-Reviewed Publication
Increased Breadth of HIV-1 Neutralization Achieved by Diverse Antibody Clones each with Limited Neutralization Breadth – December 19, 2018
Peer-Reviewed Publication
Vaccine-induced Antibodies to Herpes Simplex Virus Glycoprotein D Epitopes Involved in Virus Entry and Cell-to-cell Spread Correlate with Protection Against Genital Disease in Guinea Pigs – May 23, 2019
Peer-Reviewed Publication
Strategy for Discovery of Conventional Monoclonal Antibodies
Peer-Reviewed Publication
A Natively Paired Antibody Library Yields Drug Leads with Higher Sensitivity and Specificity Than a Randomly Paired Antibody Library – February 1, 2018
Peer-Reviewed Publication
Chickens with Humanized Immunoglobulin Genes Generate Antibodies with High Affinity and Broad Epitope Coverage to Conserved Targets – November 2, 2017
Peer-Reviewed Publication
Global Sensing of the Antigenic Structure of Herpes Simplex Virus gD Using High-throughput Array-based SPR Imaging – June 14, 2017
Peer-Reviewed Publication
Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another – January 6, 2017
Peer-Reviewed Publication
Broad Epitope Coverage of a Human in Vitro Antibody Library – November 21, 2016
Peer-Reviewed Publication
Nature Communications: Germline-encoded Neutralization of a Staphylococcus aureus Virulence Factor by the Human Antibody Repertoire
Peer-Reviewed Publication
Assessing Kinetic and Epitopic Diversity Across Orthogonal Monoclonal Antibody Generation Platforms – February 1, 2016
Peer-Reviewed Publication
The Importance of Epitope Binning for Biological Drug Discovery – June, 2014
Peer-Reviewed Publication
High-Throughput Epitope Binning of Therapeutic Monoclonal Antibodies: Why You Need to Bin the Fridge – August 1, 2014
Peer-Reviewed Publication
High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity – March 20, 2014
Application Note
Multi-Parameter Epitope-Centric Data Used to Elucidate Mechanisms of Action of Antibodies
Application Note
Reveal the Epitope Diversity of Your Antibody Library Using High Throughput SPR: A Case Study Using Progranulin
Application Note
Screening for Allosteric Competition Using High Throughput SPR
Application Note
Understanding Epitope Coverage Can Guide the Discovery of Therapeutic Antibody Cocktails for Infectious Diseases
Application Note
Using High Throughput SPR to Assess the Binding Kinetics, Affinities, and Epitope Coverage of Antibody Libraries
Brochure
Carterra Brochure: Disruptive Drug Discovery Platforms for Screening and Characterization
Brochure
eBook: Streamlining Library-to-Lead for your Antibody Therapeutics
Poster
Accelerate Kinetic Screening and Epitope Characterization of Antibody Libraries with High Throughput SPR
Poster
Accelerating the Discovery of Therapeutic Antibodies Using High Throughput SPR
Webinar
Accelerating Antibody Screening with Array-Based Surface Plasmon Resonance – January 17, 2018
We present case studies highlighting our “No Compromise Kinetics™” screening of antigens over large mAb panels in a capture format, as well as a comprehensive epitope-binning analysis on a single 384-mAb array. Results from these analyses, along with a discussion of current SPR array methodologies, will likely streamline your mAb characterization workflows significantly.
Speakers:
Kathryn Ching, PhD, Senior Scientist, Ligand Pharmaceuticals
Yasmina Noubia Abdiche, PhD, Chief Scientific Officer, Carterra
Webinar
Accelerating Drug Discovery at a Pandemic Pace
Webinar
Advances in Bispecific Antibody Discovery at Ligand Pharmaceuticals – May 14, 2020
Webinar
Antibody Discovery and Development for COVID-19 Diagnostic Testing – August 19, 2020
Webinar
Aviva Systems Biology Webinar – Immuno-oncology
Webinar
Characterization of Ion Channel Activity Blocking mAbs with High Throughput SPR – April 24, 2018
Learn how Tetragenetics has developed a strategy to generate and identify monoclonal antibodies targeting ion channels based on high-level expression of recombinant channels in Tetrahymena thermophila, enabling the development of potent immunogens and tools that allow deep mining of the immune repertoire.
Carterra’s LSA can analyze up to 384 binding interactions simultaneously, providing mAb characterization throughput to match the output of the current generation of mAb expression platforms; all antibodies can be rapidly and comprehensively screened so that unique epitopes and potential novel therapeutic candidates are not missed, while expanding IP coverage.
Speakers:
Paul Colussi, PhD, Vice President, Research, TetraGenetics
Yasmina Noubia Abdiche, PhD, Chief Scientific Officer, Carterra